Redwire and University of California San Diego researchers used the BioFabrication Facility aboard the International Space Station to print a human meniscus tissue construct in microgravity. The demonstration can help researchers study tissue engineering, but it does not show that a transplant-ready implant has been made.
TLDR: Researchers printed a human meniscus tissue construct aboard the International Space Station using Redwire’s commercial BioFabrication Facility. The sample returned to Earth for study, offering a new way to investigate tissue engineering in microgravity. It is a research demonstration, not a ready-made implant or a proven treatment.
A research team used a commercial bioprinter aboard the International Space Station to produce a small piece of human meniscus tissue, marking a notable test of how living cells can be assembled in microgravity. Redwire, the company that built and operates the station’s BioFabrication Facility, announced the result in July 2024 with researchers from the University of California San Diego.
The experiment traveled to the station on a SpaceX cargo mission in November 2023. Astronauts used Redwire’s facility to print a construct from human meniscus cells and a bio-ink designed to hold them in place. The meniscus is the crescent-shaped cartilage in the knee that cushions the joint and helps distribute force. Meniscus tissue is largely avascular, so injuries often heal poorly, particularly in its inner region. The printed sample was returned to Earth for analysis.
The work addresses a practical obstacle in tissue engineering. On Earth, gravity can cause soft printed structures to sag or lose their shape before cells and supporting material settle into a stable form. A fluid-filled environment can provide support, but it may also wash away cells or make it harder to build a precise structure. Microgravity changes those conditions, offering researchers a way to test whether delicate biological materials can be arranged with fewer gravity-driven distortions. Researchers can test whether printing conditions affect cell distribution and material architecture.
The station’s BioFabrication Facility is a small research laboratory, not a factory for replacement organs. Redwire developed the system to print biological materials in orbit, where astronauts can run experiments and researchers can compare the resulting samples with Earth-based controls. The meniscus project was a demonstration of the facility’s capabilities and an investigation into tissue formation, rather than a clinical attempt to make a transplant-ready knee implant.
That distinction matters because printing a recognizable tissue construct is only an early step. A useful meniscus replacement would need the right shape and mechanical strength, contain living cells that remain healthy, and integrate safely with surrounding tissue. It would also need to perform under the repeated loading that knees experience. The reported space-made sample does not establish that it can meet those requirements or improve patient treatment.
Still, the experiment offers a way to investigate a longstanding engineering question: whether microgravity can help produce thicker or more complex tissues than are practical on Earth. Scientists have explored space-based cell growth and tissue engineering for years, but each material and cell type behaves differently. A result with meniscus cells cannot automatically be applied to other tissues, and comparisons with matched ground samples are essential to determine what the orbital environment actually changed.
The project also shows how commercial infrastructure is becoming part of basic research in low Earth orbit. Redwire supplies equipment and operations, while university researchers contribute biological questions and analyze samples. The model can make specialized hardware available to more research teams, although orbital experiments remain costly and are limited by launch schedules, crew time and the need to return samples for testing.
The next research steps are to examine the returned construct in detail, compare it with Earth-printed samples and test whether changes in printing conditions produce stronger, more consistent tissue. Further work would need to establish cell survival, material properties and how a construct behaves in biological systems. Such measurements can guide later experiments in orbit. For now, the result is a promising proof of process: a private-sector space laboratory helped researchers print human tissue in orbit, while the route from a small sample to a reliable medical implant remains long.

